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IELTS Academic Reading Practice Test 402

Part 1 · Read the text and answer questions 1–13

You should spend about 20 minutes on Questions 1–13, which are based on Reading Passage 1 below.

The Vaccine That Soldiers Distrusted

Before piped water and sewers became normal in European cities, typhoid fever was among the most feared of infectious diseases. It is caused by a bacterium, Salmonella Typhi, which is passed in the faeces of infected people and reaches new victims through water or food that has been contaminated. The illness begins with headache and loss of appetite, and the fever climbs steadily during the first week. In the era before antibiotics perhaps one patient in five died, and some of those who recovered continued to carry the bacteria, shedding them for years afterwards.

The physician who did most to produce a defence against the disease was Almroth Wright. Born in 1861 in the village of Middleton Tyas in Yorkshire, the son of a clergyman, he studied medicine in Dublin and then spent time in Germany, where the laboratories of the great bacteriologists were transforming the subject. In 1892 he was appointed professor of pathology at the Army Medical School at Netley, on the south coast of England, and it was there that he began to think seriously about the infections that killed soldiers in wartime.

Armies had particular reason to fear typhoid. In camp, thousands of men might draw their water from the same well or stream, and once the bacterium was present it spread quickly through the ranks. The disease could empty a barracks in a matter of weeks. During the Second Boer War in South Africa, which lasted from 1899 to 1902, far more British soldiers died of disease than were killed by enemy action, and typhoid was the most lethal of those diseases. Wright had followed the work of Louis Pasteur, whose vaccines against anthrax and rabies had shown that it was possible to teach the body to resist a microbe before it was encountered, and he was convinced that the same principle could be applied to the typhoid bacillus.

His method was simple in principle. Typhoid bacteria were grown in a warm broth until there were millions of them and then killed by heat, so that they could no longer cause infection while still, Wright hoped, provoking the body's defences. In 1896 he inoculated himself and two of his assistants, and when the experiment produced no harm he began to use the preparation on volunteers. The injections were not pleasant: they frequently caused a sore arm and a bout of fever, which made some who received them reluctant to return for a second dose.

News of the vaccine travelled quickly. Medical officers in India, where typhoid was a constant danger to British troops, adopted it on a considerable scale, and Wright was able to report that inoculated regiments suffered far less from the disease than others. Not everyone was persuaded. The comparisons were not always fair, because the men who volunteered for inoculation were often those with the strongest constitutions, and the vigorous reaction that followed an injection made commanders and ordinary soldiers wary. Official committees in London examined the evidence and concluded that it was not yet conclusive, and the War Office declined to make inoculation compulsory.

A second, fiercer dispute concerned how the case should be judged. Wright measured the success of his vaccine in the laboratory, counting the bacteria that the white cells of inoculated patients were able to engulf, a technique he called the opsonic index. Critics, among them statisticians, replied that no laboratory count could settle the question, and that the only convincing evidence would come from comparing large groups of inoculated and uninoculated men living under identical conditions. Wright, who had little patience with statistical reasoning, regarded this demand as a distraction from the plain facts of the laboratory.

When the First World War broke out in 1914 the argument acquired a new urgency. The threat of typhoid returned with the armies, and the War Office finally agreed to offer inoculation to the army, though on a voluntary basis. Wright, by then the head of a large research department at St Mary's Hospital in London, campaigned publicly for it to be made compulsory, pressing his case with anyone who would listen. Take-up improved as the war went on and typhoid was brought under control, though the improvement owed as much to better sanitation and to the boiling of drinking water as to the vaccine itself.

Wright had moved to St Mary's Hospital in London in 1902 and built up there an Inoculation Department that became one of the most productive medical research centres in Britain. Among the young scientists who passed through it was Alexander Fleming, later the discoverer of penicillin. Wright himself was knighted in 1906 and lived until 1947, long enough to see the vaccine he had pioneered become standard equipment for soldiers.

The vaccine that Wright devised has long since been replaced. The whole-cell preparation caused too many reactions to be used indefinitely, and in the later twentieth century it gave way first to a purified polysaccharide injected vaccine and later to an oral vaccine made from a weakened strain of the bacterium. Yet the principle that Wright established, that a killed bacterium can be used to train the immune system against a living one, remains fundamental, and the difficulties he faced in proving his case, against resistance from the military and from the statisticians, are still familiar to anyone who has tried to introduce a new medical measure.

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Questions 1–7◎ Practise this set only

Do the following statements agree with the information given in Reading Passage 1? Choose TRUE if the statement agrees with the information, FALSE if the statement contradicts the information, and NOT GIVEN if there is no information on this.

People who recovered from typhoid could still pass the infection on to others.
Wright's father earned his living as a doctor.
In the Second Boer War, disease caused more British deaths than fighting did.
The bacteria used in the vaccine had been killed before they were injected.
Medical officers in India were unwilling to use Wright's vaccine.
Wright published the results of his vaccine trials in a medical journal.
In the end, Wright accepted the statisticians' view of how his vaccine should be assessed.

Questions 8–13◎ Practise this set only

Complete the notes below. Choose ONE WORD ONLY from the passage for each answer.

Write ONE WORD ONLY for each answer.

Wright, the First World War and the vaccine's legacy

The First World War
  • In 1914 the army was offered inoculation, but only on a basis.
  • Wright campaigned for it to be made .
  • The improvement owed much to better sanitation and to the of drinking water.
St Mary's Hospital
  • Wright's department became one of Britain's most productive medical research .
  • Wright was in 1906.
The vaccine's legacy
  • The whole-cell vaccine was abandoned because it caused too many .

About this reading test

A full IELTS Academic Reading practice test with 40 questions on three original health and medicine passages: Almroth Wright and the typhoid vaccine, how a slow sand filter makes drinking water safe, and whether bottled water should be discouraged. Includes explanations and a band estimate.

PartPassageQuestionsQuestion typesTopicsWords
1The Vaccine That Soldiers Distrusted1–13True / False / Not Given, Note completionHealth, History, Science893
2The Filter That Works by Waiting14–26Diagram label completion, True / False / Not Given, Multiple choiceInventions, Health, History910
3Should Bottled Water Be Discouraged?27–40Matching features, Yes / No / Not Given, Matching sentence endingsEnvironment, Business & Economics, Health874

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All passages and questions on Sprechify are written by our own team in the official IELTS format. They are not taken from Cambridge IELTS books or any other published test. Band scores are estimates based on the conversion commonly used for practice tests.

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